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KMID : 0616120090400020150
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 2 p.150 ~ p.154
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Inhibitory Effects of the Compounds Isolated from Sargassum yezoense on -Glucosidase and Oxidative Stress
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Lee Eun-Ha
Ham Jung-Yeob
Ahn Hong-Ryul
Kim Min-Chul
Kim Chul-Young
Pan Cheol-Ho
Um Byung-Hun
Jung Sang-Hoon
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Abstract
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We examined ethanol extracts prepared from the Korean marine algae belonging to the Sargassaceae family for their inhibitory effects on -glucosidase activity and free radicals in vitro. Among five marine algae, the extracts of Sargassum yezoense were found to possess strongly -glucosidase inhibition and free radicals scavenging activities. Two compounds were isolated via bioactivity guided isolation and tested for their effects on -glucosidase, DPPH, and analysis. Their chemical structures were elucidated by spectral analysis and direct comparison with authentic compounds; their structures were identified as sargaquinoic acid (1) and sargahydroquinoic acid (2). The inhibitory effects of compound 1 and 2 ( value:14.2 and 12.8 , respectively) on -glucosidase were more potent that of deoxynojirimycin as a positive control ( value:18.0 ). All compounds displayed antioxidative activity which was measured by DPPH, and apparatus.
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KEYWORD
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Sargassum yezoense, sargaquinoic acid, sargahydroquinoic acid, -glucosidase, antioxidative activities
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